Anderson Lab at The Ohio State University

Research

Updated August 12, 2014. Dr. Anderson is currently interested in how the liver serves as the garbage dump of the body; specifically, how the scavenger cells of liver sinusoids remove and destroy small blood-borne particles such as viruses and small immune complexes. While these functions have been ascribed almost exclusively to the Kupffer Cell (KC), we believe rather that the liver sinusoidal endothelial cell (LSEC) plays the major role. Our recent work (PLoS Pathogens, 7:e1002281, 2011) has focused on the elimination of blood-borne virus. Correcting a major misconception, we showed that the LSEC quickly (within minutes) and efficiently (>90%) eliminates blood-borne human adenovirus from mice, while the KC play a minor role. This work has been extended to test the provocative hypothesis that one of the members of the classical family of Fc receptors (FcgRIIb, the only inhibitory receptor) eliminates from the blood-stream pathogenic IgG-containing immune complexes that are too small to efficiently fix complement, thus checking the inflammatory manifestations of immune complex disease. See J. Immunol. 189:4981-4988, 2012. We are moving on to test the hypothesis that LPS is largely cleared from the blood by the LSEC.

Dr. Anderson's prior work focused on the structure and function of the classical family of Fc receptors for IgG, chiefly in human; and on the biology of FcRn, the IgG- and albumin-transporter molecule responsible for homeostasis of both of these important serum proteins and for the trans-placental transport of IgG.

Focusing on these fundamental biological questions, Dr. Anderson's lab utilizes all necessary resources and methods from the disciplines of immunology, cell and molecular biology, and biochemistry.

 

 


Room 012k Heart and Lung Institute (HLRI)
473 West Twelfth Avenue
Columbus, Ohio 43210-1228
Office: 614-247-7650
Lab: 614-247-7654

Fax: 614-247-7669
anderson.48@osu.edu